Endocrine Abstracts

Introduction: Nowadays polycystic ovarian syndrome (PCOS) appears to be one of the most common endocrine disorders that involves from 5 to 10% of women of reproductive age, reaching 75% in the structure of endocrine infertility. Furthermore the distribution of adipose tissue in android region correlates with the prognosis of diabetes, metabolic syndrome and cardiovascular diseases development.Aim of the study was to determine the type of obesity and to d...

Introduction: The number of cells in tissue is governed by two processes – the proliferation and ‘programmed cell death’ – apoptosis. Both processes in the body are controlled by enabling or inhibiting factors that are expressed on the surface of CD25+ and CD95+-lymphocytes. Somatotropin (GH) and insulin-like growth factor 1 (IGF1) stimulate proliferation, differentiation, and division of immune cells simultaneously inhibits their apoptosis and can cause tu...

Introduction: Somatotropin (GH) and insulin-like growth factor 1 (IGF1) realize their influence on the system of intracellular metabolism and a number of important biochemical lymphocytes reactions through the receptor apparatus. It is allows to use the peripheral blood lymphocytes as the investigations object of intracellular metabolism disorders in acromegaly.Aim: To study the NAD- and NADP-dependent dehydrogenases activity in blood lymphocytes in pati...

The chronic GH and IGF1 excess causes a specific changes in immune system due to presence of its receptors on T-, B-lymphocytes, granulocytes. The aim of this study was to evaluate the subpopulation composition and chemiluminescence’s indices of neutrophils in patients with active acromegaly.Thirty-three patients with active acromegaly (11 men and 22 women, mean age 51.7±11.7 years) and 53 healthy subjects sex- and age-matched with the patients...

GH and IGF1 regulate plastic and synthetic intracellular lymphocytes process. We aimed to investigate the NAD- and NADP-dependent dehydrogenases activity in blood lymphocytes in patients with active acromegaly.Thirty-three patients (11 men and 22 women, mean age 51.7±11.7 years), with the 6–10 years active phase duration of acromegaly, and 53 age- and gender matched healthy controls were determined the activity of NAD(P)-dependent dehydrogenase...

Introduction: Graves’ disease (GD) is organ-specific autoimmune-inflammatory disorder characterized by a complex pathogenesis. The inflammatory process is dominated by an imbalance of the antioxidant-oxidant mechanism, increased production of reactive oxygen species (ROS), which can potentiate the cytotoxicity of neutrophils and sustain the autoimmune process and perpetuate the disease. Aim: to study the level of ROS synthesis by peripheral blood neutrophils in patients w...

Background: Oxidative stress is involved in the pathogenesis of Graves hyperthyroidism (GH) and a disbalance of the cell redox state is associated with thyroid hyperfunction and the reccurence of the disease. Aim: To study the level of reactive oxygen species (ROS) and NAD(P)-dependent dehydrogenases of peripheral blood neutrophils in patients with compensated and relapse GH ongoing thiamazole. Materials and Methods: The study incl...

Background: Increased production of reactive oxygen species (ROS) and oxidative stress play a significant role in the initiation and persistence of the autoimmune process in Graves’ disease (GD)Aim: To study the ROS level of peripheral blood monocytes in patients with GD after radioactive iodine (RAI). Materials and Methods: The study included 48 patients with a confirmed diagnosis of GD, from 18 to 65 years (mean 46.42 ± 1...

Graves’ disease (GD) is an autoimmune disease with genetic predisposition. The link with the major histocompatibility complex determines the complexity of the excess thyroid hormones molecular action on immune system that may cause the divergence of autoimmune process in GD, functioning not only in peripheral immune cells, but also in the thyroid. Objective: to study the phenotypic composition of T- and B-lymphocyte subset patterns in peripheral blood and thyroid tissue i...

It is known that thyroid peroxidase is expressed on the apical surface of thyrocytes, where catalyze the iodination of thyroglobulin and may, also, be a surface-cell antigen, which involves in the complement-dependent cytotoxicity reactions. Objective: to study the immune status indicies depending on thyroid peroxidase (anti-TPO) antibodies in patients with Graves’ disease (GD). Materials and methods. The study included 35 women aged from 18 to 55 years, mean age of 39.1&...